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NIH Director’s Pioneer Award

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Pioneer Award Publications

Collected from Pioneer Award Recipients’ Progress Reports

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2004 PIONEER AWARD RECIPIENTS

Larry Abbott

  1. Fusi S, Drew P, Abbott LF. Cascade models of synaptically stored memories. Neuron 2005 45:599-611.
  2. Vogels TP, Abbott LF. Signal propagation and logic gating in networks of integrate-and-fire neurons. J Neurosci 2005 25:10786-95.
  3. Vogels TP, Rajan K, Abbott, LF. Neural network dynamics. Annu Rev Neurosci 2005 28:357-76.
  4. Drew PJ, Abbott LF. Extending the effects of spike-timing-dependent plasticity to behavioral timescales. Proc Natl Acad Sci U S A 2006 103:8876-81. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16731625
  5. Drew PJ, Abbott LF. Models and properties of power-law adaptation in neural systems. J Neurophysiol 2006 doi:10.1152/jn.00134.2006.
  6. Rajan K, Abbott LF. Eigenvalue spectra of random matrices for neural networks. Phys Rev Lett 2006 97:188104.
  7. Swinehart CD, Abbott LF. Dimensional reduction for reward-based learning. Network 2006 17:235-52.
  8. Fusi S, Abbott LF. Limits on the memory storage capacity of bounded synapses. Nature Neurosci 2007 10:485-93.
  9. Monaco JD, Abbott LF, Kahana MJ. Lexico-semantic structure and the word-frequency effect in recognition memory. Learn Mem 2007 14:204-13.
  10. Rajan K, Abbott LF. Temperature-compensated chemical reactions. Phys Rev E Stat Nonlin Soft Matter Phys 2007 75:022902.

George Daley

  1. Wang, Y., F. Yates, et al. (2005). "Embryonic stem cell-derived hematopoietic stem cells." Proc Natl Acad Sci U S A 102(52): 19081-6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16357205
  2. Weisberg, E., P. W. Manley, et al. (2005). "Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl." Cancer Cell 7(2): 129-41.
  3. Zaehres, H., M. W. Lensch, et al. (2005). "High-efficiency RNA interference in human embryonic stem cells." Stem Cells 23(3): 299-305.
  4. Azam, M., V. Nardi, et al. (2006). "Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance." Proc Natl Acad Sci U S A 103(24): 9244-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16754879
  5. Lensch, M. W. and G. Q. Daley (2006). "Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells." Blood 107(7): 2605-12. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16332966
  6. Zaehres, H. and G. Q. Daley (2006). "Transgene expression and RNA interference in embryonic stem cells." Methods Enzymol 420: 49-64.
  7. Kim, K., P. Lerou, et al. (2007). "Histocompatible embryonic stem cells by parthenogenesis." Science 315(5811): 482-6.
  8. Nardi, V., T. Raz, et al. (2007). "Quantitative monitoring by polymerase colony assay of known mutations resistant to ABL kinase inhibitors." Oncogene.
  9. North, T. E., W. Goessling, et al. (2007). "Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis." Nature 447(7147): 1007-11.
  10. Raz, T., V. Nardi, et al. (2007). "Farnesyl transferase inhibitor resistance probed by target mutagenesis." Blood.

Homme Hellinga

  1. Cuneo MJ, Changela A, Warren JJ, Beese LS, Hellinga HW. The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. J Mol Biol 2006 362:259-70.
  2. de Lorimier RM, Tian Y, Hellinga HW. Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. Protein Sci 2006 15:1936-44.
  3. Rizk SS, Cuneo MJ, Hellinga HW. Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. Protein Sci 2006 15:1745-51
  4. Allert M, Dwyer MA, Hellinga HW. Local encoding of computationally designed enzyme activity. J Mol Biol 2007 366:945-53. (Retracted: J Mol Biol 2008 378:759.)
  5. Cox JC, Lape J, Sayed MA, Hellinga HW. Protein fabrication automation. Protein Sci 2007 16:379-90.

Joseph McCune

  1. Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks S. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005 79:14169-78. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16254352
  2. Baum PD, McCune JM. Direct measurement of T cell receptor repertoire diversity with AmpliCot. Nat Methods 2006 3:895-901.
  3. Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos C, Hecht FM. Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses. J Virol 2006 80:6155-64. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16731954
  4. Hanley MB, Sinclair E, Navarro W, Keir M, McCune JM. A novel serum-free bone marrow microaggregate culture system. J Stem Cells 2006 1:23-4.
  5. Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, Hoh R, Martin JN, McCune JM, Waters DD, Deeks SG. Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS 2006 20:2275-83.
  6. Hunt PW, Harrigan PR, Huang W, Bates M, Williamson DW, McCune JM, Price RW, Spudich SS, Lampiris H, Hoh R, Liegler T, Neilands TB, Martin JN, Deeks SG. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. J Infect Dis 2006 194:926-30.
  7. Michaelsson J, Mold JE, McCune JM, Nixon DF. Regulation of T cell responses in the developing human fetus. J Immunol 2006 176: 5741-8.
  8. Nomura LE, Emu B, Hoh R, Haaland P, Deeks SG, Martin JN, McCune JM, Nixon DF, Maecker HT. IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. AIDS Res Ther 2006 3:18. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16859558
  9. Papasavvas E, Kostman JR, Thiel B, Pistilli M, Mackiewicz A, Foulkes A, Gross R, Jordan KA, Nixon DF, Grant R, Poulin JF, McCune JM, Mounzer K, Montaner LJ. HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption. J Clin Immunol 2006 1:40-54.
  10. Red-Horse, K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E. Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest 2006 116:2643-52, 2006. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16998586
  11. Abrams DI, Shade SB, Couey P, McCune JM, Lo J, Bacchetti P, Chang B, Epling L, Liegler T, Grant RM. Dehydroepiandrosterone (DHEA) effects on HIV-1 replication and host immunity: a randomized placebo-controlled study. AIDS Res Human Retroviruses 2007 23:77-85.
  12. Hartigan-O’Connor DJ, Poon CK, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007 319:41-52.
  13. Miller CJ, Genesca M, Abel K, Montefiore D, Forthal D, Bost K, Li J, Favre D, McCune JM. Antiviral antibodies are necessary for control of simian immunodeficiency virus replication. J Virol 2007 81:5024-35.

Steven McKnight

  1. Tu BP, Kudlicki A, Rowicka M, McKnight SL. Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes. Science 2005 310:1152-8.
  2. Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O’Hara BF, McKnight SL. NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A 2006 103:7118-23. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16636276
  3. Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proc Natl Acad Sci U S A 2007 104:2074-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17287337

Chad Mirkin

  1. Georganopoulou D, Chang L, Nam J-M, Thaxton CS, Mufson EJ, Klein WL, Mirkin CA. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A 2005 103:2273-6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15695586
  2. Liu X, Zhang Y, Goswami OK, Okasinski JS, Salaita K, Sun P, Bedzyk MJ, Mirkin CA. The controlled evolution of a polymer single crystal. Science 2005 307:1763-6.
  3. Salaita KS, Lee SW, Wang X, Huang L, Dellinger TM, Liu C, Mirkin CA. Sub-100nm, centimeter scale, parallel dip-pen nanolithography. Small 2005 1:940-5.
  4. Shaikh KA, Ryu KS, Goluch ED, Nam J-M, Liu J, Thaxton CS, Chiesl TN, Barren AE, Lu Y, Mirkin CA, Liu C. A modular microfluidic architecture for integrated biochemical analysis. Proc Natl Acad Sci U S A 2005 102:9745-50. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15985549
  5. Stoeva SI, Huo F, Lee J-S, Mirkin CA. Three-layer composite magnetic nanoparticle probes for DNA. J Am Chem Soc 2005 127:15362-3.
  6. Thaxton CS, Hill HD, Georganopoulou DG, Stoeva SI, Mirkin CA. A bio-bar-code assay based upon dithiothreitol-induced oligonucleotide release. Anal Chem 2005 77:8174-8.
  7. Vega RA, Maspoch D, Salaita K, Mirkin CA. Nanoarrays of single virus particles. Angew Chem 2005 44:6013-5.
  8. Han MS, Lytton-Jean AK, Mirkin CA. A gold nanoparticle based approach for screening triplex DNA binders. J Am Chem Soc 2006 128:4954-5.
  9. Han MS, Lytton-Jean AK, Oh B-K, Heo J, Mirkin CA. Colorimetric screening of DNA-binding molecules with gold nanoparticle probes. Angew Chem Int Ed 2006 45:1807-10.
  10. Han MS, Lytton-Jean AK, Oh BK, Heo J, Mirkin CA. Colorimetric screening of DNA binding molecules with gold nanoparticle probes. Angew Chem 2006 45:1807-10.
  11. Hill HD, Mirkin CA. The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange. Nat Protoc 2006 1:324-36.
  12. Huo F, Lytton-Jean AK, Mirkin CA. Asymmetric functionalization of nanoparticles based on thermally addressable DNA interconnects. Adv Mater 2006 18:2304-6.
  13. Hurst SJ, Lytton-Jean AK, Mirkin CA. Maximizing DNA loading on a range of gold nanoparticle sizes. Anal Chem 2006 78:8313-8.
  14. Hurst SJ, Payne EK, Qin L, Mirkin CA. Multi-component one-dimensional nanostructures. Angew Chem. 2006 45:2672-92.
  15. Hurst SJ, Payne EK, Qin L, Mirkin CA. Multisegmented one-dimensional nanorods prepared by hard-template synthetic methods. Angew Chem Int Ed 2006 45:2672-92.
  16. Jin R, Cao YC, Thaxton CS, Mirkin CA. Glass-bead-based parallel detection of DNA using composite Raman labels. Small 2006 2:375-80.
  17. Lee J-S, Stoeva SI, Mirkin CA. DNA-induced size-selective separation of mixtures of gold nanoparticles. J Am Chem Soc 2006 128:8899-903.
  18. Lee SW, Oh B-K, Sanedrin RG, Salaita K, Fujigaya T, Mirkin CA. Biologically active protein nanoarrays generated using parallel dip-pen nanolithography. Adv Mat 2006 18:1133-36.
  19. Oh B-K, Nam JM, Lee SW, Mirkin CA. A fluorophore-based bio-barcode amplification assay for proteins. Small 2006 2:103-8.
  20. Oh B-K, Park S, Millstone JE, Lee SW, Lee K-B, Mirkin CA. Separation of tricomponent protein mixtures with triblock nanorods. J Am Chem Soc 2006 128:11825-9.
  21. Oh BK, Park S, Millstone JE, Lee SW, Lee KB, Mirkin CA. Separation of tricomponent protein mixtures with triblock nanorods. J Am Chem Soc 2006 128:11825-9.
  22. Park SY, Lee JS, Georganopoulou D, Mirkin CA, Schatz GC. Structures of DNA-linked nanoparticle aggregates. J Phys Chem B 2006 770: 12673-81.
  23. Payne EK, Shuford KL, Park S, Schatz GC, Mirkin CA. Multipole plasmon resonances in gold nanorods. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2006 110:2150-4.
  24. Payne EK, Shuford KL, Park S, Schatz GC, Mirkin CA. Multipole plasmon resonances in gold nanorods. J Phys Chem B 2006 110:2150-4.
  25. Qin L, Zou S, Xue C, Atkinson A, Schatz GC, Mirkin CA. Designing, fabricating, and imaging Raman hot spots. Proc Natl Acad Sci U S A 2006 103:13300-3.
  26. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AK, Han MS, Mirkin CA. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 2006 312:1027-30.
  27. Stoeva SI, Lee J-S, Smith JE, Rosen ST, Mirkin CA. Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes. J Am Chem Soc 2006 128:8378-9.
  28. Stoeva SI, Lee J-S, Thaxton CS, Mirkin CA. Multiplexed DNA detection with biobarcoded nanoparticle probes. Angew Chem Int Ed 2006 45:3303-6.
  29. Vega RA, Maspoch D, Shen CK, Kakkassery JJ, Chen BJ, Lamb RA, Mirkin CA. Functional antibody arrays through metal ion-affinity templates. Chembiochem 2006 7:1653-7.
  30. Xu X, Rosi NL, Wang Y, Huo F, Mirkin CA. Asymmetric functionalization of gold nanoparticles with oligonucleotides. J Am Chem Soc 2006 128:9286-7.
  31. Lee JS, Han MS, Mirkin CA. Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles, Angew Chem Int Ed Engl 2007 46:4093-6.
  32. Qin L, Jang JW, Huang L, Mirkin CA. Sub-5-nm gaps prepared by on-wire lithography: correlating gap size with electrical transport. Small 2007 3:86-90.
  33. Seferos DS, Giljohann DA, Rosi NL, Mirkin CA. Locked nucleic acid-nanoparticle conjugates. Chembiochem 2007 8:1230-3.
  34. Xu X, Han MS, Mirkin CA. A gold nanoparticle-based real-time colorimetric screening method for endonuclease activity and inhibition. Angew Chem Int Ed Engl 2007 46:3468-70.

Rob Phillips

  1. Dupuy LM, Tadmr oEB, Miller RE, Phillips R. Finite-temperature quasicontinuum: molecular dynamics without all the atoms. Phys Rev Lett Epub 2005 Aug 5, 95:060202.
  2. Wiggins PA, Phillips R, Nelson PC. Exact theory of kinkable elastic polymers. Phys Rev E Stat Nonlin Soft Matter Phys Epub 2005 Feb 23, 71(2 Pt 1):021909.
  3. Ghosh K, Dill KA, Inamdar MA, Seitaridou E, Phillips R. Teaching the principles of statistical dynamics. Am J Phys 2006 74:123-33.
  4. Grayson P, Evilevitch A, Inamdar MM, Purohit PK, Gelbart WM, Knobler CM, Phillips R. The effect of genome length on ejection forces in bacteriophage lambda. Virology 2006 348:430-6.
  5. Inamdar MM, Gelbart WM, Phillips R. Dynamics of DNA ejection from bacteriophage. Biophys J 2006 91:411-20. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16679360
  6. Segall DE, Nelson PC, Phillips R. Volume-exclusion effects in tethered-particle experiments: bead size matters. Phys Rev Lett Epub 2006 Mar 3, 96:088306.
  7. Seitaridou E, Inamdar MM, Phillips R, Ghosh K, Dill K. Measuring flux distributions for diffusion in the small-numbers limit. J Phys Chem B 2007 111:2288-92.
  8. Ursell T, Huang KC, Peterson E, Phillips R. Cooperative gating and spatial organization of membrane proteins through elastic interactions. PLoS Comput Biol 2007 3(5):e81. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17480116

Stephen Quake

  1. Anderson, M. J., C. L. Hansen, et al. (2006). "Phase knowledge enables rational screens for protein crystallization." Proc Natl Acad Sci U S A 103(45): 16746-51. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17075056
  2. Liu, J., B. A. Williams, et al. (2006). "Enhanced signals and fast nucleic acid hybridization by microfluidic chaotic mixing." Angew Chem Int Ed Engl 45(22): 3618-23.
  3. Ma, Z., J. M. Gerton, et al. (2006). "Fluorescence near-field microscopy of DNA at sub-10 nm resolution." Phys Rev Lett 97(26): 260801.
  4. Ottesen, E. A., J. W. Hong, et al. (2006). "Microfluidic digital PCR enables multigene analysis of individual environmental bacteria." Science 314(5804): 1464-7.
  5. Warren, L., D. Bryder, et al. (2006). "Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR." Proc Natl Acad Sci U S A 103(47): 17807-12. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17098862
  6. Huang, Y., P. Castrataro, et al. (2007). "Solvent resistant microfluidic DNA synthesizer." Lab Chip 7(1): 24-6.
  7. Maerkl, S. J. and S. R. Quake (2007). "A systems approach to measuring the binding energy landscapes of transcription factors." Science 315(5809): 233-7.
  8. Marcy, Y., C. Ouverney, et al. (2007). "Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth." Proc Natl Acad Sci U S A 104(29): 11889-94.

Sunney Xie

  1. Evans CL, Potma EO, Puoris'haag M, Cote D, Lin CP, Xie XS. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A 2005 102:6807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16263923
  2. Kou SC, Cherayil BJ, Min W, English BP, Xie XS. Single-molecule Michaelis-Menten equations. Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2005 109:19068-81.
  3. Min W, English BP, Luo G, Cherayil BJ, Kou SC, Xie XS. Fluctuating enzymes: Lessons from single-molecule studies. Ace Chem Res 2005 38:923-31.
  4. Blainey PC, van Oijen AM, Banerjee A, Verdine GL, Xie XS. A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A 2006 103:5752-7.
  5. Cai L, Friedman N, Xie XS. Stochastic protein expression in individual cells at the single molecule level. Nature 2006 440:358-62.
  6. English BP, Min W, van Oijen AM, Lee KT, Luo G, Sun H, Cherayil BJ, Kou SC, Xie XS. Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Bio 2006 2:87.
  7. Ganikhanov F, Carrasco S, Xie XS, Katz M, Seitz W, Kopf D. Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy. Opt Lett 2006 31:1292-4.
  8. Ganikhanov F, Evans CL, Saar BG, Xie XS. High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett 2006 31:1872-4.
  9. Legare F, Evans CL, Ganikhanov F, Xie XS. Towards CARS endoscopy. Opt Express 2006 14:4427-32.
  10. Nan, Xiaolin; Potma, Eric O.; Xie, X. Sunney, Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent anti-Stokes Raman Scattering Microscopy, Biophys. J., 91, 728-735 (2006). http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16632501
  11. Xie XS, Yu J, Yang WY. Living cells as test tubes. Science 2006 312:228-30.
  12. Yu J, Xiao J, Ren X, Lao K, Xie XS. Probing gene expression in live cells, one protein molecule at a time. Science 2006 311:1600-3.
  13. Elf, Johan; Li, Gene-Wei; Xie, X. Sunney, Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell, Science, 316, 1191-1194 (2007).
  14. Friedman, Nir; Cai, Long; Xie, X. Sunney, Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression, Phys. Rev. Lett. 97, 168302 (2006).

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2005 PIONEER AWARD RECIPIENTS

Vicki Chandler

  1. Alleman, M., Sidorenko, L., McGinnis, K., Seshadri, V., Dorweiler, J.E., White, J., Sikkink, K., and Chandler, V.L. (2006) An RNA-dependent RNA polymerase is required for paramutation in maize. Nature, Jul 20;442(7100):295-8.

Hollis Cline

  1. Akerman AJ, Cline HT. Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo. J Neurosci 2006 26:5117-30.
  2. Haas K, Li J, Cline HT. (2006) AMPA receptors regulate experience-dependent dendritic arbor growth in vivo. Proc Natl Acad Sci U S A 2006 103:12127-31. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16882725
  3. Ruthazer ES, Li J, Cline HT. Stabilization of axon branch dynamics by synaptic maturation. J Neurosci 2006 26:3594-603.
  4. Van Keuren-Jensen K, Cline HT. Visual experience regulates metabotropic glutamate receptor-regulated plasticity of AMPA receptor transmission by homer1a induction. J Neurosci 2006 26:7575-80.

Leda Cosmides

  1. Cosmides L, Tooby J. Neurocognitive adaptations designed for social exchange. In Buss DM (Ed.), The Handbook of Evolutionary Psychology (pp 584-627). 2005 Hoboken NJ: Wiley.
  2. Cosmides L, Tooby J, Fiddick L, Bryant G. Detecting cheaters. Trends Cogn Sci 2005 9:505-6.
  3. Tooby J, Cosmides L. Conceptual foundations of evolutionary psychology. In Buss DM (Ed.), The Handbook of Evolutionary Psychology (pp 5-67). 2005 Hoboken NJ: Wiley.
  4. Tooby J, Cosmides L, Barrett HC. Resolving the debate on innate ideas: Learnability constraints and the evolved interpenetration of motivational and conceptual functions. In Carruthers P, Laurence S, Stich S (Eds.), The Innate Mind: Structure and Content (pp 305-37). 2005 NY: Oxford University Press.
  5. Barrett. H. C., Cosmides, L., & Tooby, J. (2006). The hominid entry into the cognitive niche. (pp. 241-248). In S. Gangestad & J. Simpson (Eds.), The Evolution of Mind. NY: Guilford.
  6. Cosmides L. The cognitive revolution: The next wave. APS Observer 2006 19:7, 23.
  7. Cosmides L, Tooby J. Evolutionary psychology, moral heuristics, and the law. In Gigerenzer G, Engel C (Eds.), Heuristics and the Law (Dahlem Workshop Report 94). 2006 Cambridge MA: MIT Press.
  8. Ermer, E., Cosmides, L. & Tooby, J. (2006). Functional specialization and the adaptationist program. (pp. 153-160). In S. Gangestad & J. Simpson (Eds.), The Evolution of Mind. NY: Guilford.
  9. Ermer, E., Guerin, S., Cosmides, L., Tooby, J., Miller M. (2006). Theory of Mind Broad and Narrow: Reasoning about social exchange engages TOM areas, precautionary reasoning does not. Social Neuroscience, 1(3-4), 196-219. (Co-published as chapter inTheory of Mind. (R. Saxe & S. Baron-Cohen, eds.). Psychology Press/Taylor & Francis Group.)
  10. Tooby, J. & Cosmides, L. (2006). The evolved architecture of hazard management: risk detection reasoning and the motivational computation of threat magnitudes. Comment on Boyer & Lienard. Behavioral and Brain Sciences 29(6), 631-633.
  11. Tooby J, Cosmides L, Price M. Cognitive adaptations for n-person exchange: The evolutionary roots of organizational behavior. Managerial and Decision Economics 2006 27:103-29.
  12. Lieberman, D., Tooby, J. & Cosmides, L. (2007). The architecture of human kin detection. Nature, 445 (7129), 727-731. (15 February 2007) + Supplementary Information.
  13. Tooby, J. & Cosmides, L. (2007). Evolutionary psychology, ecological rationality, and the unification of the behavioral sciences. Behavioral and Brain Sciences 30(1), 42-43.

Karl Deisseroth

  1. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 2005 8:1263-8.
  2. Deisseroth K., Feng G., Majewska A., Ting A.E., Miesenböck G., and Schnitzer M.J. (2006). Next-generation optical technologies. Journal of Neuroscience 26, 10380-6.
  3. Zhang F., Wang, L.P., Boyden E.S., and Deisseroth K. (2006). Channelrhodopsin-2 and optical control of excitable cells. Nature Methods 3, 785-792.
  4. Zhang F., Wang, L.P., Brauner M., Liewald J.F., Kay K., Watzke N., Wood P.G., Bamberg E., Nagel G., Gottschalk A., and Deisseroth K. (2007). Multimodal fast optical interrogation of neural circuitry. Nature 446, 633-639.

Erich Jarvis

  1. Jarvis ED. Selection for and against vocal learning in birds and mammals. Ornithology Science 2006 5:5-14.
  2. Sasaki A, Sotnikova TD, Gainetdinov RR, Jarvis ED. Social context-dependent singing-regulated dopamine J Neurosci 2006 26:9010-4.
  3. Wada K, Howard JT, McConnell P, Lints T, Rivas MV, Whitney O, Horita H, Patterson MA, White SA, Scharff C, Heasler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED. A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci U S A 2006 103:15212-7.
  4. Hara E, Kubikova L, Hessler NA, Jarvis ED. Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. (2007) Eur. J. Neurosci. 25:3406-3416
  5. Kubikova L, Turner E, Jarvis ED. The pallial-basal ganglia pathway modulates the behaviorally-driven gene expression of the motor pathway. (2007) Eur. J. Neurosci. 25:1915-2247.

Thomas Rando

  1. Conboy IM, Rando TA. Aging, stem cells, and tissue regeneration: Lessons from muscle. Cell Cycle 2005 4:407-10.
  2. Dhawan J, Rando TA. Stem cells in postnatal myogenesis: Molecular mechanisms of satellite cell quiescence, activation, and replenishment. Trends Cell Biol 2005 15:666-73.
  3. Luo D, Renault VM, Rando TA. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Devel Biol 2005 16:612-22.
  4. Rando TA. The adult muscle stem cell comes of age. Nat Med 2005 11:829-31.
  5. Shi L, Zhao G, Qiu D, Godfrey WR, Vogel H, Rando TA, Hu H, Kao PN. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of p21WAF1/CIPI and MyoD mRNAs. J Biol Chem 2005 280:18981-9.
  6. Quach NL, Rando TA. Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells. Dev Biol 2006 293:38-52.

Derek Smith

  1. Smith DJ. Predictability and preparedness in influenza control. Science 2006 312:392-4.

Giulio Tononi

  1. Huber R, Esser SK, Ferrarelli F, Massimini M, Peterson MJ, Tononi G. TMS-Induced Cortical Potentiation during Wakefulness Locally Increases Slow Wave Activity during Sleep. 1: PLoS ONE. 2007:e276 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17342210
  2. Huber R, Tononi G, Cirelli C. Exploratory behavior, cortical BDNF expression, and sleep homeostasis. Sleep. 2007 30:129-39.
  3. Massimini M, Ferrarelli F, Esser SK, Riedner BA, Huber R, Murphy M, Peterson MJ, Tononi G. Triggering sleep slow waves by transcranial magnetic stimulation. Proc Natl Acad Sci U S A. 2007, 104:8496-501.

Clare Waterman-Storer

  1. Gupton, S.L and C.M. Waterman-Storer. (2006) Spatiotemporal feedback between actomyosin and substrate adhesion dynamics optimizes rapid cell migration. Cell 125:1361-1374.
  2. Prigozhina N.P. and C.M. Waterman-Storer. (2006) Decreased polarity and increased random motility in PtK1 epithelial cells correlates with inhibition of endosomal recycling. J. Cell Sci. 119:3571-3582.
  3. Hu, K., L. JL, K. Applegate, G. Danuser and C.M. Waterman-Storer. (2007) Transmission of actin motion within focal adhesions. Science 315:111-115.

Nathan Wolfe

  1. Kalish ML, Wolfe ND, Ndongmo C, Djoko C, Robbins KE, McNicholl J, Aidoo M, Fonjungp P, Alemnji G, Mpoudi-Ngole E, Zeh C, Folks TM, Burke DS. Central African hunters exposed to SIV. Emerg Infect Dis 2005 11:1928-30. http://www.cdc.gov/ncidod/EID/vol11no12/05-0394.htm
  2. Wolfe ND, Daszak P, Kilpatrick AM, Burke DS. Bushmeat hunting, deforestation, and predicting zoonotic emergence. Emerg Infect Dis 2005 11:1822-7. http://www.cdc.gov/ncidod/eid/vol11 no12/04-0789.htm
  3. Wolfe ND, W Heneine, JK Carr, AD Barcia, V Shanmugam, U Tamoufe, JN Torimiro, AT Prosser, M LeBreton E Mpoudi-Ngole, FE McCutchan, DL Birx, TM Folks, DS Burke, WM Switzer (2005) Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters. Proc Natl Acad Sci USA. 102(22):7994-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15911757
  4. Cummings AT, WJ Moss, K Long, TJ Muluh, B Kollo, E Nomo, ND Wolfe, DS Burke (2006) Improved measles surveillance in Cameroon reveals two major dynamic patterns of incidence. International Journal of Infectious Disease 10: 148-55
  5. Gupta SB, CT Mast, ND Wolfe, V Novitsky, SA Dubey, EG Kallas, M Schechter, B Mbewe, E Vardas, P Pitisuttihum, D Burke, D Freed, R Mogg, PM Coplan, JH Condra, RS Long, K Anderson, DR Casimiro, JW Shiver, WL Straus (2006) Cross-Clade Reactivity of Anti-HIV-1 Specific T-Cell Responses in HIV-1 Infected Individuals From Botswana and Cameroon. JAIDS 42:135-139
  6. Kuniholm MH, ND Wolfe, CYH Huang, E Mpoudi-Ngole, DS Burke, DJ Gubler (2006) Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. American Journal of Tropical Medicine and Hygiene 74:1078-1083
  7. LeBreton M, AT Prosser, U Tamoufe, W Sateren, E Mpoudi-Ngole, DS Burke, ND Wolfe (2006) Patterns of hunting and perceptions of disease risk among central African communities. Animal Conservation
  8. LeBreton M, Umlauf S, Djoko C, Daszak P, Burke DS, Nwenkam PY, Wolfe ND. Rift valley fever in goats in southern Cameroon. Emerg Infect Dis 2006 12:702-3. http://www.cdc.gov/ncidod/Eid/vol12noQ4/05-1428.htm
  9. Leendertz FH, F Lankester, C Neel, O Drori, J Dupain, S Speede, P Reed, ND Wolfe, S Loul, E Mpoudi-Ngole, M Peeters, C Boesch, G Pauli, H Ellerbrok, E Leroy (2006) Anthrax joins Ebola in threatening central African great apes. American Journal of Primatology
  10. Murphy HW, M Miller, J Ramer, D Travis, R Barbiers, ND Wolfe, WM Switzer (2006) Implications of simian retroviruses for captive primate population management and the occupational safety of primate handlers. Journal of Zoo and Wildlife Management 37:219-33
  11. Ockenhouse CF, WC Hu, KE Huster, JF Cummings, A Stewart, DG Heppner, AE Jedlicka, AA Scott, ND Wolfe, M Vahey, DS Burke (2006) Common and Divergent Immune Response Signaling Pathways Discovered from Peripheral Blood Mononuclear Cell Gene Expression in Pre-symptomatic and Clinically Apparent Malaria. Infection and Immunity 74:5561-73 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16988231
  12. Steiper ME, ND Wolfe, WB Karesh, AM Kilbourn, EJ Bosi, M Ruvolo (2006) The phylogenetic and evolutionary history of a novel alpha-globin–type gene in orangutans (Pongo pygmaeus). Infect Genet Evol 6:277-286 Switzer, WM, I Hewlett, L Aaron, ND Wolfe, DS Burke, TM Folks, W Heneine (2006) Serological testing for HTLV-3 and HTLV-4. Transfusion
  13. Switzer WM, S Qari, ND Wolfe, DS Burke, TM Folks, W Heneine (2006) Ancient origin and molecular features of the novel Human T-Lymphotropic Virus Type 3 revealed by complete genome analysis. Journal of Virology http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16840323
  14. Torimiro JN, Carr JK, Wolfe ND, Karacki P, Martin MP, Gao X, Tamoufe U, Mpoudi-Ngole E, McCutchan FE, Birx DL, Burke DS, Carrington M. HLA class I diversity among rural rainforest inhabitants in Cameroon: Identification of A*2612-6*4407 haplotype. Tissue Antigens 2006 67:30-7.
  15. Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P, Wolfe ND, Shongo RL, Tshioko F, Okitolonda E, Muyembe JJ, Ryder RW, Meyer H (2007) Endemic Human Monkeypox, Democratic Republic of Congo, 2001-2004. Emerging Infectious Diseases 13:934-937
  16. Wolfe ND, C Panosian Dunavan, J Diamond (2007) Origins of major human infectious diseases. Nature 447:279- 283

Junying Yuan

  1. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005 307:935-9.
  2. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005 1:112-9.
  3. Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell 2005 123:3-5.
  4. Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ 2006 13:363-73.
  5. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, Macdonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006 281:14474-85.

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2006 PIONEER AWARD RECIPIENTS

Kwabena Boahen

  1. J V Arthur and K Boahen, “Silicon Neurons that Inhibit to Synchronize”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 4807-4810, 2006.
  2. K M Hynna and K Boahen, “Neuronal Ion-Channel Dynamics in Silicon”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 3614-3617, 2006.
  3. J Lin, P Merolla, J Arthur and K Boahen, “Programmable Connections in Neuromorphic Grids”, 49th IEEE Midwest Symposium on Circuits and Systems, IEEE Press, 2006.
  4. P A Merolla and K Boahen, “Dynamic Computation in a Recurrent Network of Heterogeneous Silicon Neurons”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 4539-4542, 2006.
  5. K M Hynna and K Boahen, “Silicon Neurons that Burst when Primed”, IEEE International Symposium on Circuits and Systems, May 2007.
  6. K M Hynna and K Boahen, “Thermodynamically-Equivalent Silicon Models of Ion Channels”, Neural Computation, vol 19, no 2, pp 327-350, February 2007.
  7. P Merolla, J Arthur, B E Shi and K Boahen, “Expandable Networks for Neuromorphic Chips”, IEEE Transactions on Circuits and Systems I, vol 54, No 2. pp. 301-311, February 2007.

Lila Gierasch

  1. Ignatova Z and Gierasch LM (2007) Effects of osmolytes on protein folding and aggregation in cells. Methods Enzymol. 428:355-372.
  2. Ignatova Z, Krishnan B, Bombardier JP, Marcelino AM, Hong J, Gierasch LM. (2007) From the test tube to the cell: exploring the folding and aggregation of a β-clam protein. Biopolymers 88:157-63.
  3. Krishnan B, Szymanska A, Gierasch LM. (2007) Site-specific fluorescent labeling of polyhistidine sequences using a metal-chelating cysteine. Chem. Biol. Drug Des. 69:31-40.

David Relman

  1. Relman DA, Versalovic J. How bacterial communities expand functional repertoires. PLoS Biology 2006; 4(12): e430. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17238278
  2. Marcy Y, Ouverney C, Bik E, Loesekann T, Martin H, Szeto E, Platt D, Hugenholtz P, Relman DA, Quake SR. Dissecting biological dark matter with single cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc Natl Acad Sci (USA) 2007; 104(29):11889-94.
  3. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biology 2007; 5(7): e177 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17594176

Younan Xia

  1. Chen, J.; McLellan, J. M.; Siekkinen, A.; Xiong, Y.; Li, Z.-Y.; Xia, Y. “Facile Synthesis of Gold-Silver Nanocages with Controllable Pores on the Surface” Journal of the American Chemical Society 2006, 128, 14776-14777.
  2. Chen, J.; Wang, D.; Xi, J.; Au, L.; Siekkinen, A.; Warsen, A.; Li, Z.-Y.; Zhang, H.; Xia, Y.; Li, X. “Immuno Gold Nanocages with Tailored Optical Properties for Targeted Photothermal Destruction of Cancer Cells” Nano Letters 2007, 7, 1318-1322.
  3. Lu, X.; Tuan, H.-Y.; Chen, J.; Li, Z.-Y.; Korgel, B.; Xia, Y. “Mechanistic Studies on the Galvanic Replacement Reaction between Multiply Twinned Particles of Ag and HAuCl4 in an Organic Medium” Journal of the American Chemical Society 2007, 129, 1733-1742.
  4. Petrova, H.; Lin, C.-H.; Hu, M.; Chen, J.; Siekkinen, A. R. Xia, Y.; Sader, J. E.; Hartland, G. V. “Vibrational response of Au-Ag Nanoboxes and Nanocages to Ultrafast Laser-Induced Heating” Nano Letters 2007, 7, 1059-1063.

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This page last reviewed: August 4, 2008